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Wednesday, April 22, 2020 | History

2 edition of Molecular and functional characterization of the protein-protein interaction between AMPA receptors and glyceraldehyde-3-phosphate dehydrogenase. found in the catalog.

Molecular and functional characterization of the protein-protein interaction between AMPA receptors and glyceraldehyde-3-phosphate dehydrogenase.

Wang, Min.

Molecular and functional characterization of the protein-protein interaction between AMPA receptors and glyceraldehyde-3-phosphate dehydrogenase.

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Published .
Written in English


About the Edition

We found that glyceraldehyde-3-phosphate dehydrogenase directly interacts with the amino-terminal domain of the AMPA receptor GluR2 subunit, and determined this interaction is located specifically in a 30 amino acid long region. This association is involved in the regulation of AMPA receptor trafficking and the AMPA receptor-mediated cell death.As both AMPA receptors and glyceraldehyde-3-phosphate dehydrogenase are important for several neurological and neuropsychiatric disease states, identifying this molecular machinery may provide novel therapeutic strategies to combat these disease entities.AMPA receptors carry the fast postsynaptic current after the presynaptic glutamate release, which is important for the initial excitation of neurons. Protein-protein interactions have been suggested to be involved in the regulation of AMPA receptors population and function. The overall goal of this research was to examine the novel protein-protein interaction between the amino-terminus of the AMPA receptor and glyceraldehyde-3-phosphate dehydrogenase and the molecular mechanisms for the regulation of AMPA receptors.

The Physical Object
Pagination81 leaves.
Number of Pages81
ID Numbers
Open LibraryOL19551925M
ISBN 109780494213841


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Molecular and functional characterization of the protein-protein interaction between AMPA receptors and glyceraldehyde-3-phosphate dehydrogenase. by Wang, Min. Download PDF EPUB FB2